Triphenylphosphine-m-sulfonate/carbon tetrabromide as an easily recoverable catalyst system for the efficient synthesis of xanthene and xanthenone derivatives under solvent-free conditions

A solid complex,readily prepared from commercially available sodium triphenylphosphine-m-sulfonate（TPPMS） and carbon tetrabromide,can be used as an easily recoverable and reusable catalyst system for one-pot condensation of 2-naphthol with aldehydes to construct 14-aryl（alkyl）-14H-dibenzo[a j]-xanthene derivatives and one-pot condensation of 2-naphthol with aldehydes and cyclic 1 3-dicarbonyl compounds to construct 12-aryl（alkyl）-8 9 10 12-tetrahydrobenzo[a]xanthen-11-one derivatives.     

Structure and magnetostriction of Tb0.4Nd0.6(Fe0.8Co0.2) x alloys

Structural, magnetic and magnetostrictive properties of Tb_0.4Nd_0.6(Fe_0.8Co_0.2) _x (1.50 ≤ x ≤ 1.90) alloys have been investigated by means of X-ray diffraction (XRD), a vibrating sample magnetometer and a standard strain technique. XRD analysis shows the presence of single Laves phase with a cubic MgCu₂-type structure for the high Nd content alloy around the composition of x = 1.80, which tends to be formed by curing at relatively low annealing temperature. The easy direction of magnetization at room temperature is observed toward <111> axis, accompanied by a rhombohedral distortion with a large spontaneous magnetostriction λ₁₁₁. An optimized effect on the linear anisotropic magnetostriction, 360 ppm at 3 kOe, was observed for the high Nd content Tb_0.4Nd_0.6(Fe_0.8Co_0.2)_1.80 alloy, which can be attributed to its single Laves phase, the large λ₁₁₁ (~1,520 ppm) of the MgCu₂-type (Tb,Nd)(Fe,Co)₂ phase and the good soft magnetic behaviors.     

A nickel oxide nanoflakes/reduced graphene oxide composite and its high-performance lithium-storage properties

Journal of Solid State Electrochemistry - Since conventional graphite-based anode possesses a low capacity, seeking for high-capacity anode candidates becomes significant for constructing emerging...     

一种新的磁共振图像处理流水线的设计与实现

磁共振图像的重建、后处理及可视化是磁共振成像（MRI）系统的重要组成部分.本文开发了一个新的用于磁共振图像重建、后处理及可视化的开源框架YAP（Yet Another Pipeline），利用此框架可以方便地构建图像处理流水线.与现有的一些其他开源框架相比，本文开发的框架具有如下特点：（1）采用基于接口的设计，可使用基于接口的插件对流水线的功能进行扩展；（2）允许用户使用编写脚本的方式构建图像处理流水线，编辑与修改流水线都很方便；（3）支持带有分支结构的流水线，便于流水线的构建与调试.目前，该框架已经在商用系统中获得了应用.     

Enhanced electrochemical performances of layered LiNi0.5Mn0.5O2 as cathode materials by Ru doping for lithium-ion batteries

Ionics - The pristine and Ru-doped LiNi0.5Mn0.5O2 cathode materials are synthesized by a wet chemical method, followed by a high-temperature calcination process. The influence of Ru substitution on...     

Screening and identification of Caulis Sinomenii bioactive ingredients with dual‐target NF‐κB inhibition and β2‐AR agonizing activities

Caulis Sinomenii (CS) is a valuable traditional medicine in China. Its extract can act as an anti‐inflammatory agent and a vascular smooth muscle relaxant. However, the underlying mechanisms remain unknown. In this study, we developed a simple dual‐target method based on ultra‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry combined with a dual‐target bioactive screening assay for anti‐inflammatory and antispasmodic activities to characterize the chemical structure of various bioactive compounds of CS rapidly. Seven potential NF‐κB inhibitors were identified, including laudanosoline‐1‐O‐xylopyranose, 6‐O‐methyl‐laudanosoline‐1‐O‐glucopyranoside, menisperine, sinomenine, laurifoline, magnoflorine and norsinoacutin. Furthermore, IL‐6 and IL‐8 assays confirmed the anti‐inflammatory effects of these potential NF‐κB inhibitors, in which laudanosoline‐1‐O‐d ‐xylopyranose and menisperine were revealed as novel NF‐κB inhibitors. Among the seven identified alkaloids, three potential β₂‐adrenergic receptor agonists, including sinomenine, magnoflorine and laurifoline, were characterized using a luciferase reporter system to measure for the activity of β₂‐adrenergic receptor agonists. Finally, sinomenine, magnoflorine and laurifoline were identified not only as potential NF‐κB inhibitors but also as potential β₂‐adrenegic receptor agonists, which is the first time this has been reported. Molecular dynamic simulation and docking results suggest that the three dual‐bioactive constituents could not only inhibit Pseudomonas aeruginosa PAK strain‐induced inflammatory responses via a negative regulation of the Braf protein that participates in MAPK signaling pathway but also activate the β₂‐adrenegic receptor. These results suggest that CS extract has dual signaling activities with potential clinical application as a novel drug for asthma.